This book offers an overview of neuroscience research performed in space since the observations made during the first manned space flights to the detailed scientific investigations currently being carried out onboard the International Space Station. This book is for the general scientific reader. Each project and the reason why it was done is described with illustrations, rationale and hypothesis, and a summary of results. Also, reference lists guide readers to the published papers from experiments. This book is a legacy of what we have learned on brain mechanisms and functions through research done in space, and a guide for what could be investigated in the future.