Primatologist Davis shares an unshakable bond with George, the extraordinarily intelligent, silverback gorilla who has been in his care since birth. When a greed-fueled corporation's genetic experiment goes awry, George and other animals across the country are mutated into aggressive super creatures that rampage the city. In an adrenaline-filled ride, Davis tries to find an antidote to not only halt a global catastrophe, but to also save the fearsome creature that was once his friend.

Originally released as a motion picture in 2018. Widescreen (16x9, 2.4:1) Special features: Not just a game anymore; Trio of destruction; Attack on Chicago; Bringing George to life; Rampage, actors in action; gag reel; deleted scenes.