Cole is sent back in time to save the human race from a deadly virus that has forced mankind into dank underground communities in the future. Along his travels, he encounters a psychiatrist and a mental patient who may hold the key to the mysterious rogue group, the Army of the 12 Monkeys, thought to be responsible for unleashing the killer disease. Believing he can obtain a pure virus sample in order to find a cure in the future, he is met with one riddle after another that puts him in a race with time.

Inspired by the film La jetée written by Chris Marker. Originally produced as a motion picture in 1995. Additional features: feature commentary with director Terry Gilliam and producer Charles Roven; The hamster factor & other tales of 12 monkeys; 12 monkeys archives.