A look at the top-secret, high-tech espionage war going on between cats and dogs, which their humans are blissfully unaware of. The film follows Mr. Tinkle's (a cat) plan to destroy a new vaccine, that if developed, would eliminate all human allergies to dogs, and allow cats to rule the world. Lou, a beagle puppy accidentally becomes the dog-agent assigned to stop the cat plan.

Special Features: Feature length audio commentary with actor Sean Hayes, director Lawrence Guterman, producer Chris Defaria, and production designer James Bissell; Behind-the-Scenes; HBO first look; Story board comparisions.