A middle of the night arrival by unmarked helicopters with secret cargo from the Middle East places the facility on high alert. When the unspeakable happens and the mysterious Subject Alpha escapes with Dr. Kathryn Ryan as a hostage, the military is forced to work with Indian Affairs agent Frank Ironhorse Whitman and his team to track the dangerous creature through Crow territory. Archaeological evidence suggests their adversary is an aged old enemy of the Crow people, with a link to the infamous fallen Watchers described in the book of Genesis. While the hunt ensues, multiple groups battle for final control of the biblical Nephilim and the potential for super soldier applications.