"This comprehensive, authoritative text presents the scientific foundations and clinical practice of neural blockade in both regional anesthesia and the management of pain. The descriptions and illustrations of pain mechanisms are considered classic examples. The Fourth Edition has been refined for clarity and flows logically from principles and pharmacology, to techniques for each anatomic region, to applications. This edition has two new co-editors and several new chapters on topics including neurologic complications, neural blockade for surgery, treatment of pain in older people, and complications in pain medicine."--Publisher.

Revised edition of: Neural blockade in clinical anesthesia and management of pain / editors, Michael J. Cousins, Phillip O. Bridenbaugh. 3rd. ed. c1998.

The history of regional anesthesia /David L. Brown and B. Raymond Fink. Part 1: Pharmacology and neurophysiology -- Neural physiology and local anesthetic action / Gary Strichartz, Els Pastijn, and Kenji Sugimoto -- Properties, absorption, and disposition of local anesthetic agents / Laurence E. Mather and Geoffrey T. Tucker -- Clinical pharmacology of local anesthetics / John F. Butterworth, IV -- Local anesthetic systemic toxicity / Graeme A. McLeod, John F. Butterworth, IV, and J.A.W. Wildsmith -- Modification of metabolic responses to surgery by neural blockade / Francesco Carli and Thomas Schricker -- Neural blockade: impact on outcome / Christopher L. Wu and Spencer S. Liu. Part II: Techniques of neural blockade in clinical anesthesia -- Perioperative management of patients and equipment selection for neural blockade / James C. Crews and Vincent W.S. Chan -- Section A: Neuraxial blockade -- Anatomy of the neuraxis / Quinn H. Hogan -- Spinal (Subarachnoid) blockade / Mikko Pitkänen -- Epidural neural blockade / Bernadette T. Veering and Michael J. Cousins -- Neurologic complications of neuraxial block / Terese T. Horlocker and Denise J. Wedel -- Section B: Peripheral block -- The upper extremity: somatic block / Joseph M. Neal -- The lower extremity: somatic blockade / F. Kayser Enneking, Denise J. Wedel, and Terese T. Horlocker -- Intravenous regional neural blockade / Per H. Rosenberg -- Section C: Thorax and abdomen / Intercostal, intrapleural, and peripheral blockade of the thorax and abdomen / Dominic C. Harmon and George D. Shorten -- Section D: Head and neck -- Somatic blockade of the head and neck / Santhanam Suresh and Narasimhan Jagannathan -- Neural blockade of oral and circumoral structures / Morton B. Rosenberg, Joseph A. Giovannitti, Jr., and James C. Phero -- Neural blockade of the eye / Kathryn E. McGoldrick and Marianne E. Feitl -- Neurologic complications of peripheral neural blockade / Hervé Bouaziz and Dan Benhamou. Part III: Applications of neural blockade in clinical anesthesia -- Neural blockade for surgery to the head and neck / Ban C.H. Tsui, Derek Dillane, and Brendan T. Finucane -- Neural blockade for cardiovascular surgery / Mark A. Chaney -- Neural blockade for abdominal and thoracic (Non-vascular) surgery / Francisco Asenjo and Francesco Carli -- Neural blockade for obstetrics and gynecologic surgery / David O. Gorman and David J. Birnbach -- Neural blockade for orthopedic surgery / Xavier Capdevila, Paul Zetlaoui, and Stephen Mannion -- Neural blockade for ambulatory surgery / Michael F. Mulroy -- Neural blockade for pediatric surgery / Bernard J. Dalens and René Truchon. Part IV: Neural blockade and the management of pain -- Section A: Physiology, pharmacology, and behavioural aspects -- Pain medicine: history, emergence as a medical specialty, and evolution of the multidisciplinary approach / Rollin M. Gallagher and Scott M. Fishman -- Socioeconomic factors in chronic pain and its management / John D. Loeser -- Developmental aspects of nociception / Suellen M. Walker -- Introduction to pain mechanisms: implications for neural blockade / Philip J. Siddall and Michael J. Cousins -- Physiologic and pharmacologic substrates of nociception after tissue and nerve injury / Tony L. Yaksh -- Pharmacologic substrates of pain: peripheral voltage gated ion channels in pain / Lucinda C. Seagrove and Anthony H. Dickenson -- Neurochemical and neurophysiological effects of neddle insertion: clinical implications / Michael J. Butler and Philip J. Siddall -- Psychological aspects of pain: implications for neural blockade. Joel Katz and Ronald Melzack -- The placebo response: implications for neural blockade / Damien G. Finniss and Fabrizio Benedetti -- Section B: Clinical assessment of persistent pain -- Assessment and diagnosis of chronic pain conditions / Christopher Vije and Michael A. Ashburn -- Diagnostic and prognostic neural blockade / Quinn H. Hogan and Stephen E. Abram -- Section C: Techniques of neural blockade and neurostimulation -- Sympathetic neural blockade of upper and lower extremity / Harald Breivik and Michael J. Cousins -- Spinal route of analgesia: opioids and future options for spinal analgesic chemotherapy / Daniel B. Carr and Michael J. Cousins -- Neurostimulation / Joshua P. Prager and Michael Stanton-Hicks -- Percutaneous neural destructive techniques / David Niv and Michael Gofeld -- Section D: Applications, complications, and the future -- Acute pain management and acute pain services / Pamela E. MacIntyre and David A. Scott. Spinal pain and the role of neural blockade / James P. Rathmell, Carlos A. Pino, and Shihab Ahmed -- Treatment of cancer pain: role of neural blockade and neuromodulation / Allen W. Burton, Phillip C. Phan, and Michael J. Cousins -- Complex regional pain syndrome, including applications of neural blockade / Andreas Binder and Ralf Baron -- The treatment of pain in neonatal and pediatric patients / Constance S. Houck [and others] -- The treatment of pain in older patients / Robert D. Helme and Julia A. Fleming -- Palliative care and pain control in older persons and those with terminal illness / Perry G. Fine -- Complications in pain medicine / James P. Rathmell -- New Horizons / Allan I. Basbaum.