This book summarizes the current knowledge, including biology and epidemiology, clinical features, and management regarding diseases of the breast. It is ideal for clinicians who see patients with breast disease, especially carcinoma of the breast.

Breast anatomy and development. Breast anatomy and development -- Stem cells in breast development and carcinogenesis: concepts and clinical perspectives -- Diagnosis and management of benign breast disease. Physical examination of the breast -- Management of the palpable breast mass -- Management of disorders of the ductal system and infections -- Management of breast pain -- Abnormalities of the breast in pregnancy and lactation -- Management of gynecomastia -- Pathology of benign breast disorders -- Breast imaging and image-guided biopsy techniques. Breast cancer screening -- Imaging analysis: mammography -- Imaging analysis: ultrasonography -- Imaging analysis: magnetic resonance imaging -- New breast imaging techniques -- Image-guided biopsy of nonpalpable breast lesions -- Epidemiology and assessing and managing risk. Inherited genetic factors and breast cancer -- Genetic testing and management of patients with hereditary breast cancer -- Nongenetic factors in the causation of breast cancer -- Management of other high risk patients -- Chemoprevention -- In situ carcinoma. Ductal carcinoma in situ and other intraductal lesions: pathology, immunohistochemistry, and molecular alterations -- Lobular carcinoma in situ: biology and management -- Ductal carcinoma in situ and microinvasive carcinoma -- Pathology and biological markers of invasive breast cancer. Genomic events in breast cancer progression -- Pathology of invasive breast cancer -- Estrogen and progesterone receptor testing for prognosis and prediction -- HER2/ERBB2 testing: assessment of status for targeted therapies -- Clinical and pathologic prognostic and predictive factors -- Genomics, prognosis, and therapeutic interventions -- Bone marrow micrometastases and circulating tumor cells -- Management of primary invasive breast cancer. Evaluation of patients for metastasis prior to primary therapy -- Staging of breast cancer -- Mastectomy -- Contralateral prophylactic mastectomy -- Breast-conserving therapy -- Breast reconstruction -- Sentinel lymph node biopsy -- Axillary dissection -- Preserving and restoring function after local treatment -- Lymphedema -- Local management of the axilla -- Postmastectomy radiation therapy -- Adjuvant systemic therapy: endocrine therapy -- Adjuvant systemic chemotherapy in early breast cancer -- Adjuvant chemo endocrine therapy -- Adjuvant and preoperative systemic therapy for HER2-positive breast cancer -- Adjuvant systemic therapy: bone-targeted treatments -- Pharmacogenomics of systemic therapy -- Implications of obesity in breast cancer -- Lifestyle issues in breast cancer survivors -- Management of menopausal symptoms in breast cancer survivors -- Long-term and late effects of primary curative intent therapy: neurocognitive, cardiac, and secondary malignancies -- Adjuvant systemic therapy treatment guidelines. Preoperative systemic therapy. Preoperative chemotherapy for operable breast cancer -- Preoperative endocrine therapy for operable breast cancer -- Pathologic assessment of treatment response after neoadjuvant therapy -- Local-regional therapy following systemic treatment -- Locally advanced breast cancer -- Inflammatory breast cancer -- Preoperative systemic therapy for breast cancer --Special therapeutic problems. Male breast cancer -- Phyllodes tumors -- Paget's disease -- Nonepithelial malignancies of the breast -- Breast cancer during pregnancy and subsequent pregnancy in breast cancer survivors -- Occult primary cancer with axillary metastases -- Evaluation after primary therapy and management of recurrent breast cancer. Surveillance of patients following primary therapy -- Surgery for the primary in patients with distant metastases -- Management of local regional recurrences after primary breast cancer treatment -- Treatment of metastatic breast cancer: endocrine -- Treatment of metastatic breast cancer: chemotherapy -- Treatment of HER2-overexpressing metastatic breast cancer -- Palliative care in breast cancer -- Management summary for the care of patients with metastatic breast cancer -- New breast cancer therapeutic approaches. Newer targeted therapy -- Site-specific therapy of metastatic breast cancer. Brain metastases -- Metastatic epidural spinal cord compression -- Leptomeningeal metastasis -- Brachial plexopathy in patients with breast cancer -- Ophthalmic metastases -- Management of isolated liver metastases -- Medical treatment for bone metastases -- Local management of bone metastases -- Breast cancer in specific populations. Breast cancer in older women -- Breast cancer in younger women -- Breast cancer in minority women -- Issues in breast cancer survivorship. Nursing care in patient management and quality of life -- Overview of survivorship issues -- Psychosocial adaptation during and after breast cancer -- Reproductive issues in breast cancer survivors -- Cost and cost effectiveness considerations.