Introduction to pharmacokinetics and pharmacodynamics -- Basic pharmacokinetics -- Half-life, elimination rate, and AUC -- Intravenous bolus administration, multiple drug administration, and steady-state average concentrations -- Relationships of pharmacokinetic parameters and intravenous intermittent and continuous infusions -- Two-compartment models -- Biopharmaceutics : absorption -- Drug distribution and protein binding -- Drug elimination processes -- Nonlinear processes -- Pharmacokinetic variation and model-independent relationships -- Aminoglycosides -- Vancomycin -- Theophylline -- Phenytoin and digoxin.