Front Cover -- Kaufman's Atlas of Mouse Development Supplement -- Copyright Page -- Dedication -- Contents -- List of Contributors -- 1 Introduction -- 2 Coronal Sections -- Introduction -- Methods -- Results -- Discussion -- Acknowledgments -- References -- 3 A Revised Staging of Mouse Development Before Organogenesis -- Introduction -- Methods -- Overview of the Revised Staging System, TS1-12 -- Anatomy of Stages with Representative Molecular Markers -- Preimplantation Stages: TS1-5, E0 to E3.5 (Figure 3.1) -- From Implantation to the Prestreak Stage: TS6-9a, E4.5-6.5 (Figure 3.2) -- Early Primitive Streak to Late Pre-Headfold. TS9b-11b, E 6.5-E7.5 (Figure 3.3) -- Early Headfold to Early Somitogenesis. TS11a-12, E7.5-8 (Figure 3.4) -- Timing and Litter Variation -- Discussion -- Acknowledgments -- References -- 4 Development of Early Embryonic Lineages -- Introduction -- Preimplantation Development -- Formation of outer and inner cells of the blastocyst (TS3-4 E2.5-3) -- Formation of the primitive endoderm (TS4-5 E3-3.5) -- Postimplantation Development -- Implantation (TS6 E4.5) -- Specification of the embryonic anteroposterior axis (by TS7d E5.75) -- Initiation of gastrulation (TS9a-b E6.25-6.5) -- Formation of definitive endoderm (TS9b-10b E6.5-7.0) -- Formation of the primitive central nervous system (TS9a E6.5 onwards) -- Formation of mesoderm (TS9b E6.5 onward) -- Amnion formation (TS9b-11a E6.5-7.5) -- Function of the node (TS9b-TS12 E6.5-8.0) -- The notochord: Axial mesendoderm (TS10a-TS12 E7.0-8.0) -- Left/right patterning (TS11d-TS12 E7.5-8.0) -- Initiation of somitogenesis and the restriction of potency in the epiblast (TS11d E8.0 onwards) -- Discussion and prospects -- Acknowledgment -- References -- 5 The Alimentary Canal -- Introduction -- Current Views and Molecular Mechanisms of Developing Gut Anatomy. Morphogenesis and patterning of the gut tube -- Foregut morphogenesis and patterning -- Midgut morphogenesis and patterning -- Hindgut morphogenesis and patterning -- Additional aspects of alimentary canal patterning -- Concluding Remarks -- References -- 6 The Pancreas -- Introduction -- The Current View of the Developmental Anatomy of the Pancreas -- Formation of the pancreatic anlagen (E8.5-10.5) -- Morphogenesis and fusion of the pancreatic anlagen (E10.5-17.5) -- Morphogenesis of the spleen -- The adult pancreas -- Discussion -- References -- 7 Development of the Heart and Great Vessels -- Addition of Cardiac Populations to the Early Heart Tube -- Atrial Septation -- Formation and Incorporation of the Pulmonary Vein -- Septation and Separation of the OFT -- Discussion -- References -- 8 Ontogeny of the Hematopoietic System -- Introduction -- Sites of Hematopoietic Progenitor Generation -- The yolk sac: Two waves of hematopoietic progenitors generation -- The para-aortic splanchnopleura/aorta-gonads-mesonephros: hematopoietic stem cells generation -- Midgestation Hematopoietic Sites -- Fetal liver -- Fetal thymus -- Late Gestation-Perinatal Hematopoietic Sites -- Spleen -- Bone marrow -- Conclusion -- Abbreviations -- References -- 9 The Reproductive System -- Introduction -- The Early Stages -- Formation of the intermediate mesoderm -- Primordial germ cells (PGCs) -- The Indifferent or Bipotential Stage -- Female Development -- Male Development -- Discussion -- Acknowledgments -- References -- 10 Development of the Respiratory System -- Overview -- Foregut morphogenesis, and establishment of trachea and primary lung buds -- Structure of the trachea -- Branching morphogenesis of the primary lung buds up to about E14.5 -- Branching, morphogenesis, and differentiation of the endoderm after E14.5. Development of the pulmonary blood supply, alveologenesis and the early postnatal growth, and remodeling and maturation of ... -- Lineage tracing of lung mesoderm -- Differentiation and function of lung mesothelium -- Discussion -- References -- 11 The Urinary System -- Introduction -- The Current View of the Developmental Anatomy of the System -- New Lineage Data -- Discussion -- Further Resources -- References -- 12 Integument and Associated Integumentary Appendages -- Introduction: The Structural Diversity of the Mouse Integument -- Early Integumental Development -- Specification of discrete domains in the ectoderm -- Origin, migration, and formation of the dermis -- Cornea, Interfollicular Skin, and Pilosebaceous Units -- Cornea -- Interfollicular skin -- Different types of hairs, their patterns, and time schedules -- Molecular mechanisms involved in the formation of hair placodes and subsequent cellular proliferation -- Hair follicle morphogenesis and segregation of two types of stem cells in the developing pilosebaceous unit -- Development of the sebaceous gland and related glandular structures -- The Mammary Gland -- Formation of the mammary line and associated mesenchyme -- Formation of the specific types of mammary placodes -- Formation of the embryonic mammary gland -- Other Ducted Cutaneous Glands -- Eccrine sweat glands -- Salivary glands -- Lacrimal and Harderian glands -- Discussion -- References -- 13 The Axial Musculoskeletal System -- Introduction -- The Current View of the Developmental Anatomy of the System -- Developmental anatomy of the segmentation process -- Somite differentiation -- The sclerotome -- The dermomyotome and the myotome -- The syndetome -- New Lineage Data -- Sclerotome -- Dermomyotome and myotome -- Discussion -- References -- 14 Spinal Cord and Peripheral Nervous System -- Introduction. The Current View of the Developmental Anatomy of the Spinal Cord and the Peripheral Nervous System -- Neurulation and neural tube defects -- Anteroposterior patterning and segmental organization of the spinal cord -- Segmental organization of the peripheral nervous system -- Segmental neural crest cell migration -- Segmental organization of somatic and sympathetic efferent nerves -- Development of the parasympathetic nervous system: a special case -- The enteric nervous system -- Dorsoventral patterning of the neural tube -- The development of neuronal pathways within the spinal cord -- General principles -- The formation of sensory-motor connections -- The formation of motor columns -- Formation of spinal nerves -- The refinement of connections -- Discussion -- Acknowledgments -- References -- 15 Limb Development -- Introduction -- AnatomicAL Features of the Early Limb Bud -- Limb Initiation and Specification -- Limb Outgrowth -- Proximodistal axis -- Anteroposterior axis -- Integrating proximodistal and anteroposterior signaling -- Dorsoventral axis -- Programmed cell death -- Chondrogenesis and joint formation -- Tendon and ligament development -- Muscle formation -- Conclusion -- References -- 16 The Craniofacial Region -- Introduction -- The Current View of the Developmental Anatomy of the Head and Neck -- Early morphogenesis of the cranial region and formation of the pituitary and pineal glands -- Origin of the craniofacial tissue components -- The embryonic face and pharynx -- Early development -- Pharyngeal arches, pouches, and clefts -- Cranial nerves -- Melanocytes -- The skull -- The skull base -- The skull vault and face -- Discussion -- Acknowledgments -- References -- 17 Recent Advances in Palate and Tongue Development -- Introduction -- The Current View of the Developmental Anatomy of the Palate and Tongue -- Palate development. Patterning of the palatal shelves -- Elevation of the palatal shelves -- Palatal shelf growth: proliferation of the CNCC-derived mesenchyme -- Palatal fusion -- Soft palate development -- Tongue development -- Myogenic lineage in the developing tongue -- Cranial neural crest-derived mesenchyme in the developing tongue -- Myogenic stem cells, tongue disease, and therapeutic perspectives -- Discussion -- References -- 18 The Developmental Anatomy of Teeth -- Introduction -- The Current View of the Developmental Anatomy of Teeth -- The dental lamina -- Tooth placodes -- Enamel knots -- Stem cells in the continuously growing mouse incisor -- New lineage data -- Discussion -- Acknowledgments -- References -- 19 Brain Development -- Introduction -- The Current View of the Developmental Anatomy of the Mouse Brain -- Neural Induction, neurulation, and early regionalization -- The Developmental Anatomy of the Mouse Cerebral Neocortex -- The origin and migration of cortical neurons -- Pyramidal cells and radial migration -- Interneuron generation and tangential migration -- Cell death during early cortical development -- Mechanisms Controlling Development of the Mouse Cerebral Neocortex -- Extrinsic and intrinsic influences on cortical development -- Thalamic and thalamocortical development -- Formation of maps in the cortex -- Connectivity between regions -- Mouse barrel formation: an example of map formation -- Plasticity during development -- Development of the Mouse Cerebellum -- Cerebellar specification -- Genesis of the cerebellum -- The Formation of cerebellar connections -- Conclusions -- Acknowledgments -- References -- 20 The Visual System -- Introduction -- The Current View of the Developmental Anatomy of the Visual System -- Establishing the Eye Field -- Signals -- Transcription Factors -- Separating the Eye Field. Optic Vesicle Patterning and Morphogenesis.