Mortality in COPD: The Role of Comorbidities /Don D. Sin -- The Role of Systemic Inflammation in COPD / Kristina L. Bailey, Jadvinder Goraya, and Stephen L. Rennard -- The Disablement Process in COPD / Michael D.L. Morgan -- Cardiovascular Disease / Thierry Troosters -- Osteoporosis / Luis F. Diez-Morales and Vincent Cunanan -- Thoracic Malignancies / Matthew D. Jankowich -- Anxiety and Depression / Vincent S. Fan and Nicholas D. Giardino -- Cognitive Function / Paula Meek -- Skeletal Muscle Dysfunction / Marc-André Caron, Marie-Eve Thériault, Richard Debigaré, and François Maltais -- Inactivity / Judith Garcia-Aymerich -- Body Composition Abnormalities / Bram van den Borst and Annemie M.W.J. Schols -- COPD, Comorbidity, and Disease-Specific Clinical Practice Guidelines / Kristina Frogale, Kerry M. Schnell, and Cynthia M. Boyd -- Pharmacologic Treatment Strategies / Rachael A. Evans, Robert G. Varadi, Kambiz Mirzaei, and Roger S. Goldstein -- Pulmonary Rehabilitation: Targeting the Systemic Manifestations of COPD / Linda Nici and Richard ZuWallack -- Disease Management and Integrated Care / Emiel F.M. Wouters and Ingrid M.L. Augustin.