V.1. General biologic processes -- Strategies for understanding the lung in health and disease -- Major components -- Epithelium -- Endothelium -- Interstitium -- Mobile cells -- Pleura -- Chest wall -- Integrated morphology: growth and form -- Morphogenesis -- Integral design of human lung -- Integrated physiology and pathophysiology -- Mechanics -- v. 2. Integrated physiology and pathophysiology -- Pulmonary circulation and fluid exchange -- Pulmonary gas exchange -- Control of ventilation -- Peripheral gas exchange -- Oxygen demand and bioenergetics of exercise -- Oxygen delivery to muscle cells -- Hypoxemia and ischemia -- Exercise -- Sleep -- Fetal, perinatal, postnatal, and aging lung -- Fetal and perinatal -- Postnatal growth -- Aging lung -- Lung injury, defense, and repair -- Proteases and antiproteases -- Oxidants and antioxidants -- Particulates -- Infections and host defenses -- Immune injury -- Contaminants in the air -- Other forms of injury -- Fibrotic processes -- Genetic modulation of susceptibility to lung disease -- Normal and abnormal growth in lung cells -- Special environments and interventions -- Special environments -- Interventions.